Reflex Seizures Triggered by Diaper Change in Dravet Syndrome.
نویسندگان
چکیده
Dravet syndrome (DS) is a severe epilepsy syndrome characterized by early onset of multiple types of seizures. We report the first case of reflex seizures triggered by diaper change in a girl at 9 months old and 2 years old with a mutation in the SCN1A gene causing DS. Reflex seizures have been reported in patients with DS provoked by increased body temperature or visual stimulation. The case we report widens the spectrum of triggers causing reflex seizures in children with DS. Cortical hyperexcitability resulting from the genetic defect explains the tendency to experience such reflex seizures.
منابع مشابه
Dravet syndrome: from electroclinical characteristics to molecular biology.
The onset of Dravet syndrome typically occurs within the first year, with prolonged, generalized, or unilateral clonic seizures triggered by fever. In the early stages, other types of refractory seizures usually present that include myoclonic seizures, atypical absences, and partial seizures. Electroencephalography (EEG) findings are not pathognomonic, and signs of cognitive arrest or deteriora...
متن کاملDravet Syndrome: Diagnosis and Long-Term Course.
Dravet syndrome is one of the most severe epilepsy syndromes of early childhood, and it comes with very high morbidity and mortality. The typical presentation is characterized by hemiclonic or generalized clonic seizures triggered by fever during the first year of life, followed by myoclonic, absence, focal and generalized tonic-clonic seizures. Non-convulsive status epilepticus and epileptic e...
متن کاملPhysical Education Intervention in a Child with Dravet Syndrome: A Case Study
Background. Dravet syndrome (DS) is an early-onset epileptic encephalopathy that leads to gross and fine motor skills deficits. Objectives. This study aimed to evaluate the results of a motor intervention program in a child with DS. Methods. We analyzed uma child with DS during the 3-year intervention in Physical Education. Interviews with the child’s mother and the teachers’ class diary were...
متن کاملTrial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.
BACKGROUND The Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for the treatment of drug-resistant seizures in the Dravet syndrome. METHODS In this double-blind, placebo-controlled trial, we randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizu...
متن کاملPrevalence of SCN1A-Related Dravet Syndrome among Children Reported with Seizures following Vaccination: A Population-Based Ten-Year Cohort Study
OBJECTIVES To determine the prevalence of Dravet syndrome, an epileptic encephalopathy caused by SCN1A-mutations, often with seizure onset after vaccination, among infants reported with seizures following vaccination. To determine differences in characteristics of reported seizures after vaccination in children with and without SCN1A-related Dravet syndrome. METHODS Data were reviewed of 1,26...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
دوره 43 4 شماره
صفحات -
تاریخ انتشار 2016